Items 1 to 10 of about 406528
1. Izu A, Solomon F, Nzenze SA, Mudau A, Zell E, O'Brien KL, Whitney CG, Verani J, Groome M, Madhi SA: Pneumococcal conjugate vaccines and hospitalization of children for pneumonia: a time-series analysis, South Africa, 2006-2014. Bull World Health Organ; 2017 Sep 01;95(9):618-628
HIV InSite. treatment guidelines - HIV InSite .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pneumococcal conjugate vaccines and hospitalization of children for pneumonia: a time-series analysis, South Africa, 2006-2014.
  • METHODS: We used data collected at the Chris Hani Baragwanath Hospital in Soweto between 2006 and 2014 - i.e. before and after April 2009, when a pneumococcal conjugate vaccine was first included in South Africa's routine immunization programme.
  • Using a Bayesian generalized seasonal autoregressive moving-average model and the data collected in 2006-2008, we estimated the numbers of children that would have been hospitalized for pneumonia between 2010 and 2014 if no pneumococcal conjugate vaccines had been used.
  • FINDINGS: Between 2006 and 2014, 26 778 children younger than five years - including 3388 known to be infected with human immunodeficiency virus (HIV) - were admitted to the study hospital for pneumonia.
  • We estimated that, for the children known to be infected with HIV and for the other children, pneumococcal conjugate vaccines reduced the numbers of hospitalizations for pneumonia in 2014 by 33% (50% credible interval, CrI: 6 to 52) and 39% (50% CrI: 24 to 50), respectively.
  • In the study hospital in 2012-2014, as a result of immunizations with these vaccines, there were an estimated 3100 fewer pneumonia hospitalizations of children younger than five years.

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  • (PMID = 28867842.001).
  • [ISSN] 1564-0604
  • [Journal-full-title] Bulletin of the World Health Organization
  • [ISO-abbreviation] Bull. World Health Organ.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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2. Whittaker R, Economopoulou A, Dias JG, Bancroft E, Ramliden M, Celentano LP, European Centre for Disease Prevention and Control Country Experts for Invasive Haemophilus influenzae Disease: Epidemiology of Invasive Haemophilus influenzae Disease, Europe, 2007-2014. Emerg Infect Dis; 2017 Mar;23(3):396-404

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidemiology of Invasive Haemophilus influenzae Disease, Europe, 2007-2014.
  • We describe the epidemiology of invasive Haemophilus influenzae disease during 2007-2014 in 12 European countries and assess overall H. influenzae disease trends by serotype and patient age.
  • Mean annual notification rate was 0.6 cases/100,000 population, with an increasing annual trend of 3.3% (95% CI 2.3% to 4.3%).
  • The notification rate was highest for patients <1 month of age (23.4 cases/100,000 population).

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  • (PMID = 28220749.001).
  • [ISSN] 1080-6059
  • [Journal-full-title] Emerging infectious diseases
  • [ISO-abbreviation] Emerging Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Europe / bacteria / coccobacillus / epidemiology / invasive Haemophilus influenzae disease / invasive disease / invasive pathogen / serotype / surveillance / temporal trends / vaccine
  • [Investigator] Steindl G; Martiny D; Grammens T; Georgieva T; Maikanti-Charalampous P; Koliou M; Lebedova V; Krizova P; Dalby T; Valentiner-Branth P; Epstein J; Kerbo N; Toropainen M; Kuusi M; Georges S; Lepoutre A; Takla A; Lam TT; Georgakopoulou T; Tzanakaki G; Molnár Z; Gudnason T; Hardardottir H; O'Lorcain P; Meyler K; D'Ancona F; Cerquetti M; Savrasova L; Galajeva J; Gargasienė G; Caruana P; Melillo T; Mollema L; Spanjaard L; Steinbakk M; Paradowska-Stankiewicz I; Kuch A; Pinto CS; Lavado P; Stanescu A; Giuca MC; Novakova E; Kastrin T; Vitek MG; Pérez-Vázquez M; Cano R; Lepp T; Morfeldt E; Ladhani S; McDonald E
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3. Park J, Han E, Lee SO, Kim DS: Antibiotic use in South Korea from 2007 to 2014: A health insurance database-generated time series analysis. PLoS One; 2017;12(5):e0177435
MedlinePlus Health Information. consumer health - Antibiotics.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Antibiotic use in South Korea from 2007 to 2014: A health insurance database-generated time series analysis.
  • The goal of this study was to explore antibiotic usage patterns in South Korea using 2007-2014 health insurance claims data.
  • RESULTS: Antibiotic use in DID increased from 23.5 in 2007 to 27.7 in 2014.
  • The ≤ 6 years old age group showed the highest level of usage at 59.21 DID in 2014, and showed an increasing trend each year.

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  • (PMID = 28520761.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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4. Enkhbold B, Shatar M, Wakamori S, Tamura T, Hiono T, Matsuno K, Okamatsu M, Umemura T, Damdinjav B, Sakoda Y: Genetic and virulence characterization of classical swine fever viruses isolated in Mongolia from 2007 to 2015. Virus Genes; 2017 Jun;53(3):418-425

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic and virulence characterization of classical swine fever viruses isolated in Mongolia from 2007 to 2015.
  • Classical swine fever (CSF), a highly contagious viral disease affecting domestic and wild pigs in many developing countries, is now considered endemic in Mongolia, with 14 recent outbreaks in 2007, 2008, 2011, 2012, 2014, and 2015.
  • For the first time, CSF viruses isolated from these 14 outbreaks were analyzed to assess their molecular epidemiology and pathogenicity in pigs.
  • Based on the nucleotide sequences of their 5'-untranslated region, isolates were phylogenetically classified as either sub-genotypes 2.1b or 2.2, and the 2014 and 2015 isolates, which were classified as 2.1b, were closely related to isolates from China and Korea.
  • Experimental infection of the representative isolate in 2014 demonstrated moderate pathogenicity in 4-week-old pigs, with relatively mild clinical signs.

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  • (PMID = 28260187.001).
  • [ISSN] 1572-994X
  • [Journal-full-title] Virus genes
  • [ISO-abbreviation] Virus Genes
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Classical swine fever / Experimental infection / Phylogenetic analysis / Virulence / Virus isolation
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5. Henkle E, Hedberg K, Schafer SD, Winthrop KL: Surveillance of Extrapulmonary Nontuberculous Mycobacteria Infections, Oregon, USA, 2007-2012. Emerg Infect Dis; 2017 10;23(10):1627-1630

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surveillance of Extrapulmonary Nontuberculous Mycobacteria Infections, Oregon, USA, 2007-2012.
  • We describe results from statewide population-based laboratory surveillance in Oregon, USA, during 2007-2012.
  • Compared with pulmonary NTM infection, more extrapulmonary infections are caused by rapid-growing NTM species. the designation of NTM as a reportable disease in Oregon in 2014 will result in better detection of changes in the incidence and patterns of disease in the future.

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  • (PMID = 28930014.001).
  • [ISSN] 1080-6059
  • [Journal-full-title] Emerging infectious diseases
  • [ISO-abbreviation] Emerging Infect. Dis.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / HHSN272201200005C
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Mycobacterium avium complex (major topic) / Oregon (major topic) / Public health surveillance (major topic) / bacteria (major topic) / extrapulmonary nontuberculous mycobacteria (major topic) / incidence (major topic) / nontuberculous mycobacteria (major topic) / tuberculosis and other mycobacteria (major topic)
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6. Bynum JA, Wang X, Stavchansky SA, Bowman PD: Time Course Expression Analysis of 1[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole Induction of Cytoprotection in Human Endothelial Cells. Gene Regul Syst Bio; 2017;11:1177625017701106

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Time Course Expression Analysis of 1[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole Induction of Cytoprotection in Human Endothelial Cells.
  • 1[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im), a synthetic derivative of oleanolic acid that exhibits antioxidant and anti-inflammatory activity in several animal and in vitro models, has been shown to be beneficial if given after injury.
  • Time-course gene expression profiling was performed on HUVEC treated with CDDO-Im for 0.5, 1, 3, 6, and 24 hours.

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  • (PMID = 28469413.001).
  • [ISSN] 1177-6250
  • [Journal-full-title] Gene regulation and systems biology
  • [ISO-abbreviation] Gene Regul Syst Bio
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; CDDO-IM / Microarray / cytoprotection / time-course gene expression
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7. Nissen J, Jokelainen P, Stensvold CR, Trevisan C, Fuchs J, Burgdorf KS, Nielsen HV, Pires SM: The disease burden of congenital toxoplasmosis in Denmark, 2014. PLoS One; 2017;12(5):e0178282
Genetic Alliance. consumer health - BabysFirstTest - Congenital Toxoplasmosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The disease burden of congenital toxoplasmosis in Denmark, 2014.
  • METHODS: Using data primarily from two public health surveillance programmes conducted between 1992 and 2007, we estimated the incidence, occurrence of sequelae, mortality and the burden of disease in terms of disability-adjusted life years (DALYs) of CT in Denmark in 2014.
  • FINDINGS: We estimated that 14 children were born with CT in 2014, of which six will have developed sequelae by the age of 12.
  • A comparison of the estimated incidence of CT with the number of reported CT cases in 2008-2014 indicated that for each reported CT case, at least five other CT cases could be expected to have occurred and gone unreported.

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  • (PMID = 28558051.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Misra-Hebert AD, Hu B, Klein EA, Stephenson A, Taksler GB, Kattan MW, Rothberg MB: Prostate cancer screening practices in a large, integrated health system: 2007-2014. BJU Int; 2017 Aug;120(2):257-264
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prostate cancer screening practices in a large, integrated health system: 2007-2014.
  • We conducted a retrospective cohort study using electronic medical record data from January 2007 to December 2014.
  • RESULTS: Annual PSA-screening testing declined from 2007 to 2014 in all age groups, as did biennial and quadrennial screening.
  • Yearly rates declined for men aged ≥70 years, from 22.8% to 8.9%; ages 50-69 years, from 39.2% to 20%; and ages 40-49 years, from 11% to 4.6%.
  • While the number of men screened and rates of follow-up prostate cancer screening declined in 2011-2014 compared to 2007-2010, similar re-screening rates were noted for men aged 45-75 years with initial PSA levels of <1 ng/mL or 1-3 ng/mL in both the earlier and later cohorts.
  • Rates of prostate biopsy declined for men aged ≥70 years in 2014 compared to 2007.
  • For men who had PSA screening, rates of first prostate biopsy increased in later years for A-A men and men with a family history of prostate cancer.
  • CONCLUSIONS: Prostate cancer screening declined from 2007 to 2014 even in higher-risk groups and follow-up screening rates were not related to previous PSA level.
  • However, rates of first prostate biopsy in men who were screened with a PSA test were higher for men with an increased risk of prostate cancer in later years.

  • Genetic Alliance. consumer health - Prostate cancer.
  • MedlinePlus Health Information. consumer health - Prostate Cancer.
  • MedlinePlus Health Information. consumer health - Prostate Cancer Screening.
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  • [Copyright] © 2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd.
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  • (PMID = 28139034.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Grant] United States / AHRQ HHS / HS / K08 HS024128; United States / NCATS NIH HHS / TR / KL2 TR000440; United States / NCATS NIH HHS / TR / UL1 TR000439
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
  • [Keywords] NOTNLM ; #PCSM / #ProstateCancer / cancer screening / primary care
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9. Chen Z, Kolor K, Grosse SD, Rodriguez JL, Lynch JA, Green RF, Dotson WD, Bowen MS, Khoury MJ: Trends in utilization and costs of BRCA testing among women aged 18-64 years in the United States, 2003-2014. Genet Med; 2017 Sep 21;

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trends in utilization and costs of BRCA testing among women aged 18-64 years in the United States, 2003-2014.
  • PurposeWe examined 12-year trends in BRCA testing rates and costs in the context of clinical guidelines, national policies, and other factors.MethodsWe estimated trends in BRCA testing rates and costs from 2003 to 2014 for women aged 18-64 years using private claims data and publicly reported revenues from the primary BRCA testing provider.ResultsThe percentage of women with zero out-of-pocket payments for BRCA testing increased during 2013-2014, after 7 years of general decline, coinciding with a clarification of Affordable Care Act coverage of BRCA genetic testing.
  • Beginning in 2007, family history accounted for an increasing proportion of women with BRCA tests compared with personal history, coinciding with BRCA testing guidelines for primary care settings and direct-to-consumer advertising campaigns.
  • During 2013-2014, BRCA testing rates based on claims grew at a faster rate than revenues, following 3 years of similar growth, consistent with increased marketplace competition.
  • In 2013, BRCA testing rates based on claims increased 57%, compared with 11% average annual increases over the preceding 3 years, coinciding with celebrity publicity.ConclusionThe observed trends in BRCA testing rates and costs are consistent with possible effects of several factors, including the Affordable Care Act, clinical guidelines and celebrity publicity.GENETICS in MEDICINE advance online publication, 21 September 2017; doi:10.1038/gim.2017.118.

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  • (PMID = 28933789.001).
  • [ISSN] 1530-0366
  • [Journal-full-title] Genetics in medicine : official journal of the American College of Medical Genetics
  • [ISO-abbreviation] Genet. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Dela Paz NG, Melchior B, Frangos JA: Shear stress induces Gα&lt;sub&gt;q/11&lt;/sub&gt; activation independently of G protein-coupled receptor activation in endothelial cells. Am J Physiol Cell Physiol; 2017 Apr 01;312(4):C428-C437

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Shear stress induces Gα<sub>q/11</sub> activation independently of G protein-coupled receptor activation in endothelial cells.
  • In this study, we used in situ proximity ligation assay (PLA) to investigate the role of a specific GPCR/Gα<sub>q/11</sub> pair in EC shear stress-induced mechanotransduction.
  • We demonstrated that sphingosine 1-phosphate (S1P) stimulation causes a rapid dissociation at 0.5 min of Gα<sub>q/11</sub> from its receptor S1P<sub>3</sub>, followed by an increased association within 2 min of GPCR kinase-2 (GRK2) and β-arrestin-1/2 with S1P<sub>3</sub> in human coronary artery ECs, which are consistent with GPCR/Gα<sub>q/11</sub> activation and receptor desensitization/internalization.
  • The G protein activator AlF<sub>4</sub> resulted in increased dissociation of Gα<sub>q/11</sub> from S1P<sub>3</sub>, but no increase in association between S1P<sub>3</sub> and either GRK2 or β-arrestin-1/2.
  • Shear stress also caused the rapid activation within 7 s of S1P<sub>3</sub>/Gα<sub>q/11</sub> There were no increased associations between S1P<sub>3</sub> and GRK2 or S1P<sub>3</sub> and β-arrestin-1/2 until 5 min.
  • GDP-β-S, but not VPC23019, prevented dissociation of Gα<sub>q/11</sub> from S1P<sub>3</sub> in response to shear stress.
  • These findings suggest that Gα<sub>q/11</sub> participates in the sensing/transducing of shear stress independently of GPCR activation in ECs.

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  • [Copyright] Copyright 2017 © the American Physiological Society.
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  • (PMID = 28148497.001).
  • [ISSN] 1522-1563
  • [Journal-full-title] American journal of physiology. Cell physiology
  • [ISO-abbreviation] Am. J. Physiol., Cell Physiol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R37 HL040696
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lysophospholipids; 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Lysosphingolipid; 0 / spingosine-1-phosphate receptor 4, mouse; 26993-30-6 / sphingosine 1-phosphate; EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gq-G11; NGZ37HRE42 / Sphingosine
  • [Keywords] NOTNLM ; G protein-coupled receptors / endothelial cell / heterotrimeric G proteins / shear stress
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