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1. Peltzer K, Pengpid S: Sleep Duration, Sleep Quality, Body Mass Index, and Waist Circumference among Young Adults from 24 Low- and Middle-Income and Two High-Income Countries. Int J Environ Res Public Health; 2017 May 26;14(6)

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sleep Duration, Sleep Quality, Body Mass Index, and Waist Circumference among Young Adults from 24 Low- and Middle-Income and Two High-Income Countries.
  • The aim of this study was to explore the relationship between body mass index (BMI), waist circumference (WC) and sleep patterns, including duration and disturbances.
  • A cross-sectional questionnaire survey and anthropometric measurements were conducted with undergraduate university students that were randomly recruited in 26 universities in 24 low- and middle-income and two high-income countries.
  • The sample included 18,211 (42.1% male and 57.9% female, mean age 21.0 in male and 20.7 years in female students) undergraduate university students.

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  • (PMID = 28587107.001).
  • [ISSN] 1660-4601
  • [Journal-full-title] International journal of environmental research and public health
  • [ISO-abbreviation] Int J Environ Res Public Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Keywords] NOTNLM ; body mass index / low- and middle-income countries / sleep duration / sleep quality / waist circumference / young adults
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2. Schjørring S, Stegger M, Kjelsø C, Lilje B, Bangsborg JM, Petersen RF, David S, Uldum SA, ESCMID Study Group for Legionella Infections (ESGLI): Genomic investigation of a suspected outbreak of Legionella pneumophila ST82 reveals undetected heterogeneity by the present gold-standard methods, Denmark, July to November 2014. Euro Surveill; 2017 Jun 22;22(25)

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genomic investigation of a suspected outbreak of Legionella pneumophila ST82 reveals undetected heterogeneity by the present gold-standard methods, Denmark, July to November 2014.
  • Between July and November 2014, 15 community-acquired cases of Legionnaires´ disease (LD), including four with Legionella pneumophila serogroup 1 sequence type (ST) 82, were diagnosed in Northern Zealand, Denmark.
  • Four putative-outbreak ST82 isolates were retrospectively subjected to whole genome sequencing (WGS) followed by phylogenetic analyses with epidemiologically unrelated ST82 sequences.
  • The four putative-outbreak ST82 sequences fell into two clades, the two clades were separated by ca 1,700 single nt polymorphisms (SNP)s when recombination regions were included but only by 12 to 21 SNPs when these were removed.

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  • [Copyright] This article is copyright of The Authors, 2017.
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  • (PMID = 28662761.001).
  • [ISSN] 1560-7917
  • [Journal-full-title] Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
  • [ISO-abbreviation] Euro Surveill.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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3. Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS, Ketelbey JW, Boyd A, Walker BR: Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™). Br J Pharmacol; 2017 Mar;174(5):396-408
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).
  • BACKGROUND AND PURPOSE: Reducing glucocorticoid exposure in the brain via intracellular inhibition of the cortisol-regenerating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has emerged as a therapeutic strategy to treat cognitive impairment in early Alzheimer's disease (AD).
  • We sought to discover novel, brain-penetrant 11β-HSD1 inhibitors as potential medicines for the treatment of AD.
  • EXPERIMENTAL APPROACH: Medicinal chemistry optimization of a series of amido-thiophene analogues was performed to identify potent and selective 11β-HSD1 inhibitors with optimized oral pharmacokinetics able to access the brain.
  • Single and multiple ascending dose studies were conducted in healthy human subjects to determine the safety, pharmacokinetic and pharmacodynamic characteristics of the candidate compound.
  • RESULTS: UE2343 was identified as a potent, orally bioavailable, brain-penetrant 11β-HSD1 inhibitor and selected for clinical studies.
  • No major safety issues occurred in human subjects.
  • Plasma adrenocorticotropic hormone was elevated (a marker of systemic enzyme inhibition) at doses of 10 mg and above, but plasma cortisol levels were unchanged.
  • Following multiple doses of UE2343, plasma levels were approximately dose proportional and the terminal t<sub>1/2</sub> ranged from 10 to 14 h.
  • The urinary tetrahydrocortisols/tetrahydrocortisone ratio was reduced at doses of 10 mg and above, indicating maximal 11β-HSD1 inhibition in the liver.
  • Concentrations of UE2343 in the CSF were 33% of free plasma levels, and the peak concentration in CSF was ninefold greater than the UE2343 IC<sub>50</sub> .
  • CONCLUSIONS AND IMPLICATIONS: UE2343 is safe, well tolerated and reaches the brain at concentrations predicted to inhibit 11β-HSD1.
  • UE2343 is therefore a suitable candidate to test the hypothesis that 11β-HSD1 inhibition in brain improves memory in patients with AD.

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  • [Copyright] © 2016 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
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  • (PMID = 28012176.001).
  • [ISSN] 1476-5381
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Grant] United Kingdom / British Heart Foundation / / RG/11/4/28734
  • [Publication-type] Journal Article
  • [Publication-country] England
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4. Ge LL, Han ZY, Liu AH, Zhu L, Meng JH: [Antibiotic resistance analysis of &lt;i&gt;Streptococcus pneumoniae&lt;/i&gt; isolates from the hospitalized children in Shanxi Children's Hospital from 2012 to 2014]. Zhonghua Er Ke Za Zhi; 2017 Feb 02;55(2):109-114

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Antibiotic resistance analysis of <i>Streptococcus pneumoniae</i> isolates from the hospitalized children in Shanxi Children's Hospital from 2012 to 2014].
  • <b>Method:</b> E-test and Kirby-Bauer methods were applied to determine drug sensitivity of the isolates collected from the body fluid specimens of hospitalized children in Shanxi Children's Hospital from January 2012 to December 2014.
  • <b>Result:</b> A total of 671 isolates of streptococcus pneumoniae were obtained, which could be divided as non-invasive isolates(607), invasive isolates from non-cerebrospinal fluid(non-CSF)(40) and invasive isolates from cerebrospinal fluid(CSF)(24).
  • From 2012 to 2014, the susceptibility rates of non-invasive isolates to penicillin every year were 95.0%(96/101), 97.3%(110/113), 87.3%(343/393), respectively, and there was significant difference among the three years(χ(2)=13.266, <i>P</i><0.05), and the values of MIC(50, )MIC(90) and the maximum values of MIC(mg/L) of penicillin were 0.064, 2.000, 6.000 in 2012, which grew up to 1.000, 3.000, 16.000 in 2014.
  • On the other hand, the values of MIC(50, )MIC(90) and the maximum value of MIC(mg/L) of ceftriaxone and cefotaxime both increased from 0.500, 2.000, 8.000 in 2012 to 0.750, 4.000, 32.000 in 2014.
  • Based on the same examining standard of CSF, the antimicrobial sensitivity(isolates(%)) of the non-invasive isolates to ceftriaxone, cefotaxime, SMZ-TMP were respectively 281(46.3%), 278(45.8%), 78(12.9%), were significantly lower than the susceptibility rate of the invasive isolates from non-CSF (28(70%), 28(70%), 14(35%), χ(2)=8.453, 8.817, 15.094, all <i>P</i><0.012 5), and lower than the invasive isolates from CSF (18(75%), 18(75%), χ(2)=7.631, 7.905, <i>P</i><0.012 5; 11(45.8%), <i>P</i>=0.001).
  • The susceptibility rate of penicillin of non-invasive Streptococcus pneumoniae declined by these years, and the differences to ceftriaxone and cefotaxime can be neglected, but the values of MIC(50, )MIC(90) and the maximum value of MIC of all were linearly rising.
  • The susceptibility rate of antibiotics to ceftriaxone and cefotaxime of the non-invasive isolates was lower than the invasive isolates.
  • <b>目的:</b> 了解山西省儿童医院住院部肺炎链球菌分离株的耐药状况。 <b>方法:</b> 收集2012年1月至2014年12月山西省儿童医院住院患儿各类体液标本中肺炎链球菌分离株,用E-test法和纸片扩散法进行药敏试验,分析肺炎链球菌对主要抗菌药物敏感率及最低抑菌浓度(MIC)等情况,比较非侵袭性肺炎链球菌耐药性的年度变化及不同标本来源肺炎链球菌的耐药性差异。率的比较采用Fisher确切概率法或χ(2)检验。 <b>结果:</b> 收集了671株肺炎链球菌,其中非侵袭性分离株607株,非脑脊液侵袭性分离株40株,脑脊液分离株24株。671株肺炎链球菌分离株对抗菌药物敏感性[株(%)]依次为:万古霉素671(100.0%),利奈唑胺671(100.0%),左氧氟沙星665(99.1%),青霉素595(88.7%),头孢曲松516(76.9%),头孢噻肟512(76.3%),磺胺甲基异噁唑-甲氧苄氨嘧啶(SMZ-TMP)103(15.4%),克林霉素28(4.2%),四环素26(3.9%),红霉素12(1.8%)。肺炎链球菌非侵袭性分离株对青霉素的敏感率2012—2014年分别为95.0%(96/101)、97.3%(110/113)、87.3%(343/393),3年间比较差异有统计学意义(χ(2)=13.266, <i>P</i><0.05),且2012年青霉素的MIC(50)、MIC(90)、最大MIC值(mg/L)分别为0.064、2.000、6.000,2014年上升至1.000、3.000、16.000;2012-2014年非侵袭性分离株对头孢曲松、头孢噻肟的敏感率3年间比较差异无统计学意义(χ(2)=1.172、1.198, 均<i>P</i>>0.05),但头孢曲松、头孢噻肟MIC(50)、MIC(90)、最大MIC值(mg/L)均由2012年的0.500、2.000、8.000上升至2014年的0.750、4.000、32.000;非侵袭性分离株对其余抗菌药物3年间的耐药状况的比较差异无统计学意义(<i>P</i>>0.05)。统一按肺炎链球菌脑膜炎静脉注射给药折点判断,607株非侵袭性分离株对头孢曲松、头孢噻肟、SMZ-TMP的敏感株数分别为281(46.3%)、278(45.8%)、78(12.9%),低于非脑脊液侵袭性分离株(40株)的敏感株数[28(70%)、28(70%)、14(35%),χ(2)=8.453、8.817、15.094,均<i>P</i><0.012 5],亦低于脑脊液分离株(24株)的敏感株数[18(75%)、18(75%),χ(2)=7.631、7.905,<i>P</i><0.012 5;11(45.8%),<i>P</i>=0.001];不同标本来源肺炎链球菌分离株对其余抗菌药物的耐药状况比较差异无统计学意义(<i>P</i>>0.05)。 <b>结论:</b> 2012—2014年山西省儿童医院住院患儿肺炎链球菌对万古霉素、利奈唑胺、左氧氟沙星等敏感率均超过95.0%,对青霉素、头孢曲松、头孢噻肟的敏感率分别为88.7%、76.9%、76.3%,对红霉素、克林霉素、SMZ-TMP、四环素等敏感率均低于20.0%;3年间非侵袭性分离株对青霉素的敏感率下降,对头孢曲松、头孢噻肟的敏感率无明显变化,但MIC(50)、MIC(90)、最大MIC水平上升;非侵袭性分离株对头孢曲松、头孢噻肟、SMZ-TMP的敏感率低于侵袭性分离株。.

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  • (PMID = 28173648.001).
  • [ISSN] 0578-1310
  • [Journal-full-title] Zhonghua er ke za zhi = Chinese journal of pediatrics
  • [ISO-abbreviation] Zhonghua Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Keywords] NOTNLM ; Child / Drug resistance / Streptococcus pneumoniae
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5. Cabrera-Gaytán DA, Niebla-Fuentes MD, Padilla-Velázquez R, Valle-Alvarado G, Arriaga-Nieto L, Rojas-Mendoza T, Rosado-Quiab U, Grajales-Muñiz C, Vallejos-Parás A: Association of Pulmonary Tuberculosis and HIV in the Mexican Institute of Social Security, 2006-2014. PLoS One; 2016;11(12):e0168559
HIV InSite. treatment guidelines - Adherence to HIV Antiretroviral Therapy .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of Pulmonary Tuberculosis and HIV in the Mexican Institute of Social Security, 2006-2014.
  • The objective of this study was to analyze the incidence trends of pulmonary TB and HIV comorbidity and treatment outcomes according to HIV during the period 2006 to 2014 in the Mexican Institute of Social Security.
  • METHODS: Analyzed data from this registry including pulmonary tuberculosis patients aged 15 years and older who had been diagnosed during the years 2006 to 2014 in the Mexican Institute of Social Security.
  • RESULTS: During the study period, 31,352 patients were registered with pulmonary tuberculosis.
  • The incidence rate observed during 2014 was 11.6 case of PTB per 100,000.
  • The pulmonary TB with HIV incidence rate decreased by 16.3% during the study period (In women increase 4.81% and in man decrease 21.6%).

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  • (PMID = 28033402.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Mell T, Jacob L, Fuhr I, Dick S, Rapp MA, Kostev K: Patterns of benzodiazepine prescribing by neuropsychiatrists and general practitioners for elderly patients in Germany in 2014
. Int J Clin Pharmacol Ther; 2017 Jun;55(6):466-471
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Patterns of benzodiazepine prescribing by neuropsychiatrists and general practitioners for elderly patients in Germany in 2014
.
  • METHODS: This study included 31,268 and 6,603 patients between the ages of 65 and 100 with at least one benzodiazepine prescription in 2014 from GP and NP, respectively.
  • Lorazepam (30.3%), oxazepam (24.7%), and bromazepam (24.3%) were the three most commonly prescribed drugs for GP patients.
  • In contrast, lorazepam (60.4%), diazepam (14.8%), and oxazepam (11.2%) were those more frequently prescribed to NP patients.

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  • (PMID = 28406089.001).
  • [ISSN] 0946-1965
  • [Journal-full-title] International journal of clinical pharmacology and therapeutics
  • [ISO-abbreviation] Int J Clin Pharmacol Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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7. Brinker TJ, Owczarek AD, Seeger W, Groneberg DA, Brieske CM, Jansen P, Klode J, Stoffels I, Schadendorf D, Izar B, Fries FN, Hofmann FJ: A Medical Student-Delivered Smoking Prevention Program, Education Against Tobacco, for Secondary Schools in Germany: Randomized Controlled Trial. J Med Internet Res; 2017 Jun 06;19(6):e199

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A Medical Student-Delivered Smoking Prevention Program, Education Against Tobacco, for Secondary Schools in Germany: Randomized Controlled Trial.
  • A recent quasi-experimental study showed significant short-term smoking cessation effects on 11-to-15-year-old adolescents.
  • OBJECTIVE: The aim of this study was to provide the first randomized long-term evaluation of the optimized 2014 EAT curriculum involving a photoaging software for its effectiveness in reducing the smoking prevalence among 11-to-15-year-old pupils in German secondary schools.
  • METHODS: A randomized controlled trial was undertaken with 1504 adolescents from 9 German secondary schools, aged 11-15 years in grades 6-8, of which 718 (47.74%) were identifiable for the prospective sample at the 12-month follow-up.
  • The differences in smoking behavior (smoking onset, quitting) between the two groups, as well as gender-specific effects, were studied as secondary outcomes.
  • From baseline to the two follow-up time points, the prevalence of smoking increased from 3.1% to 5.2% to 7.2% in the control group and from 3.0% to 5.4% to 5.8% in the intervention group (number needed to treat [NNT]=68).
  • Notable differences were observed between the groups for the female gender (4.2% to 9.5% for control vs 4.0% to 5.2% for intervention; NNT=24 for females vs NNT=207 for males), low educational background (7.3% to 12% for control vs 6.1% to 8.7% for intervention; NNT=30), and migrational background (students who claimed that at least one parent was not born in Germany) at the 12-month follow-up.

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  • (PMID = 28588007.001).
  • [ISSN] 1438-8871
  • [Journal-full-title] Journal of medical Internet research
  • [ISO-abbreviation] J. Med. Internet Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; adolescents / medical students / school-based prevention / secondary schools / smoking cessation / tobacco prevention
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8. Lendowski L, Walger P, Hoeser C, Exner M, Roesing C, Engelhart S: [Rational Use of Antibiotics Data form a Survey from 2014 within the mrdo Network Compared to Nationwide Data from 2009]. Gesundheitswesen; 2017 Jun 19;

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Rational Use of Antibiotics Data form a Survey from 2014 within the mrdo Network Compared to Nationwide Data from 2009].
  • [Transliterated title] Rationaler Antibiotikaeinsatz Daten aus dem mre-netz regio rhein-ahr aus einer Umfrage von 2014 und Vergleich mit bundesweiten Daten von 2009.
  • <b>Objective</b> To detect weaknesses when prescribing antibiotics in hospitals and compare the situation between 2009 and 2014.
  • <b>Methods</b> In 2014, a questionnaire was sent to all 380 physicians employed in 7 hospitals.
  • Primary, secondary and tertiary care hospitals were included.
  • 119 completed questionnaires of 2014 were compared to 3 613 obtained in 2009.
  • <b>Results</b>31% of the questionnaires were returned.
  • 23% of interns reported they would advise colleagues daily and 61% at least once a week.
  • <b>Conclusion</b> Despite improvement compared to 2009, 38.9% of all physicians asked did not know their regional antibiotic resistant data and half of all surgeons still used surgical prophylaxis longer than 24 h.
  • <b>Ziel</b> Erkennen von Schwächen bei Antibiotikaverschreibungen in Krankenhäusern und Vergleich zwischen 2009 und 2014.
  • <b>Methoden</b> Ein Fragebogen wurde 2014 an alle 380 Ärzte von 7 Krankenhäusern, der Grund-, Regel- und Maximalversorgung verteilt.
  • Die 119 beantworteten Fragebögen von 2014 wurden mit den 3613 aus 2009 verglichen.
  • <b>Ergebnisse</b> 31% der Fragebögen wurden zurückgeschickt, 53,8% von Assistenzärzten, die Hälfte ohne Facharztanerkennung.
  • 23% der Assistenzärzte gaben an, täglich andere Kollegen zu beraten und 61% mind.
  • <b>Schlussfolgerung</b> Trotz Verbesserung im Vergleich zu 2009 kannten 38,9% der Befragten die antibiotische Resistenzlage in ihrem Haus nicht und die Hälfte aller Chirurgen setzte die perioperative Prophylaxe länger als 24 Stunden ein.

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 28628930.001).
  • [ISSN] 1439-4421
  • [Journal-full-title] Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))
  • [ISO-abbreviation] Gesundheitswesen
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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9. Shadaker S, Magee M, Paz-Bailey G, Hoots BE, NHBS Study Group: Characteristics and Risk Behaviors of Men Who Have Sex With Men and Women Compared With Men Who Have Sex With Men-20 US Cities, 2011 and 2014. J Acquir Immune Defic Syndr; 2017 Jul 01;75 Suppl 3:S281-S287
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characteristics and Risk Behaviors of Men Who Have Sex With Men and Women Compared With Men Who Have Sex With Men-20 US Cities, 2011 and 2014.
  • METHODS: Data for this analysis were from MSM who participated in National HIV Behavioral Surveillance in 2011 and 2014.
  • RESULTS: Overall, 2042 (11.9%) participants were classified as MSMW.
  • MSMW were more likely than MSMO to have given money or drugs for sex (aPR 2.85; 95% CI: 2.52 to 3.24) or received money or drugs for sex (aPR 2.64; 95% CI: 2.37 to 2.93) and to ever have injected drugs (aPR 2.05; 95% CI: 1.80 to 2.34).
  • MSMW had more total sex partners (median 6, interquartile range: 4-11 vs. 3, 2-8), casual sex partners (5, 2-10 vs. 3, 1-7), and condomless sex partners (2, 1-4 vs. 1, 0-2) in the last 12 months (P < 0.01 for all comparisons).

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  • (PMID = 28604429.001).
  • [ISSN] 1944-7884
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Wang FZ, Zhang GM, Shen LP, Zheng H, Wang F, Miao N, Yuan QL, Sun XJ, Bi SL, Liang XF, Wang HQ: [Comparative analyze on hepatitis B seroepidemiological surveys among population aged 1-29 years in different epidemic regions of China in 1992 and 2014]. Zhonghua Yu Fang Yi Xue Za Zhi; 2017 Jun 06;51(6):462-468

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Comparative analyze on hepatitis B seroepidemiological surveys among population aged 1-29 years in different epidemic regions of China in 1992 and 2014].
  • <b>Objective:</b> To evaluate the effect of hepatitis B prevention and control by comparative analysis on the results of HBsAg, anti-HBs and anti-HBc prevalence from national hepatitis B seroepidemiological surveys in 1992 and 2014 in different epidemic regions of China.
  • <b>Methods:</b> Data was from the national seroepidemiological surveys of hepatitis B conducted in 1992 and 2014.
  • The survey in 2016 was conducted in 160 disease surveillance points of 31 provinces (excluding Hong Kong, Macao Special Administrative Region and Taiwan province) in China.
  • We analyzed unweighted point prevalence and 95<i>% CI</i> of HBsAg, anti-HBs and anti-HBc in 1992 which had no design weighting, and analyzed weighted point prevalence and 95<i>%CI</i> of HBsAg, anti-HBs and anti-HBc in 2014 which had design weighting.
  • <b>Results:</b> 34 291 and 31 713 people aged 1-29 years were involved in 1992 and 2014 national serosurveys of China, respectively.
  • For the people aged 1-29 years, HBsAg prevalence was 2.64% (95<i>%CI:</i> 2.28%-3.06%) in 2014 and decreased by 73.92% as compared with the rate 10.13% (95<i>% CI:</i> 9.81%-10.45%) in 1992.
  • Anti-HBc prevalence was 13.01% (95<i>%CI:</i> 12.09%-14.00%) in 2014 and decreased by 71.61% as compared with the rate 45.84% (95<i>% CI:</i> 45.31%-46.37%) in 1992.
  • Anti-HBs prevalence was 57.79% (95<i>%CI:</i> 56.33%-59.25%) in 2014 and ascended by 127.41% as compared with the rate 25.41% (95<i>% CI:</i> 24.95%-25.87%) in 1992.
  • In high, medium and low epidemic region, for the people who born during 1992-2001 when hepatitis B vaccine was introduced in routine immunization management, HBsAg prevalence was 4.74% (95<i>%CI:</i> 3.79%-5.69%), 1.59% (95<i>%CI:</i> 1.09%-2.10%) and 2.53% (95<i>%CI:</i> 1.66%-3.39%), respectively, and anti-HBs prevalence was 64.25% (95<i>% CI:</i> 62.11%-66.39%), 56.34% (95<i>% CI:</i> 54.50%-58.57%), 54.49% (95<i>%CI:</i> 51.75%-57.23%), respectively, and anti-HBc prevalence was 15.16% (95<i>%CI:</i> 13.56%-16.76%), 11.07% (95<i>%CI:</i> 9.80%-12.33%), 7.61% (95<i>%CI:</i> 6.15%-9.07%), respectively.
  • In high, medium and low epidemic region, for the people who born during 2002-2013 the duration which hepatitis B vaccine was integrated in expanded immunization program born during when HBsAg prevalence was 0.88% (95<i>%CI:</i> 0.66%-1.11%), 0.37% (95<i>%CI:</i> 0.24%-0.49%)and 0.71% (95<i>%CI:</i> 0.48%-0.94%), respectively, and anti-HBs prevalence was 60.74% (95<i>%CI:</i> 59.57%-61.90%), 59.46% (95<i>%CI:</i> 58.44%-60.49%), 52.56% (95<i>% CI:</i> 51.20%-53.92%), respectively, and anti-HBc prevalence was 3.30% (95<i>% CI:</i> 2.87%-3.72%), 1.91% (95<i>%CI:</i> 1.63%-2.20%), 2.25% (95<i>%CI</i>: 1.85%-2.66%), respectively.
  • HBsAg prevalence among people aged 1-29 years old in 2014 decreased dramatically as compared with that in 1992.
  • Since hepatitis B vaccine was integrated into expanded immunization program, China reduced HBsAg prevalence to less than 1% among people aged 1-12 years in 2014 in different epidemic region.
  • <b>目的:</b> 分析比较中国1992和2014年不同流行地区1~29岁人群乙型肝炎血清学指标阳性率,评价乙型肝炎预防控制效果。 <b>方法:</b> 数据来自于1992年全国病毒性肝炎血清流行病学调查和2014年全国乙型肝炎血清流行病学调查数据。1992年调查覆盖内地30个省份(不包括中国香港、澳门、台湾数据)145个疾病监测点;2014年调查覆盖内地31个省份(不包括中国香港、澳门、台湾数据)160个疾病监测点。两次调查均采用入户或集中调查的方式,问卷调查内容包括出生日期、性别、民族、地区等。问卷调查后,采集静脉血5 ml,检测HBsAg、抗-HBs、抗-HBc。1992年调查数据计算相关指标阳性率及其95<i>%CI</i>值为样本数据;2014年调查按设计权重加权估计相关指标阳性率及其95<i>%CI</i>值。 <b>结果:</b> 1992年共调查1~29岁人群34 291名,2014年为31 713名。2014年HBsAg阳性率为2.64%(95<i>%CI</i>:2.28%~3.06%),较1992年(10.13%,95<i>%CI</i>:9.81%~10.45%)下降73.92%;2014年抗-HBc阳性率为13.01%(95<i>%CI</i>:12.09%~14.00%),较1992年(45.84%,95<i>%CI</i>:45.31%~46.37%)下降71.61%;2014年抗-HBs阳性率为57.79%(95<i>% CI</i>:56.33%~59.25%),较1992年(25.41%,95<i>% CI</i>:24.95%~25.87%)上升127.41%。乙型肝炎疫苗纳入计划免疫管理后出生人群(即1992—2001年出生),2014年高、中、低流行区该人群HBsAg阳性率分别为4.74%(95<i>%CI</i>:3.79%~5.69%)、1.59%(95<i>%CI</i>:1.09%~2.10%)、2.53%(95<i>% CI</i>:1.66%~3.39%),抗-HBs阳性率分别为64.25%(95<i>% CI</i>:62.11%~66.39%)、56.34%(95<i>%CI</i>:54.50%~58.57%)、54.49%(95<i>%CI</i>:51.75%~57.23%),抗-HBc阳性率分别为15.16%(95<i>%CI</i>:13.56%~16.76%)、11.07%(95<i>%CI</i>:9.80%~12.33%)、7.61%(95<i>%CI</i>:6.15%~9.07%)。乙型肝炎疫苗纳入免疫规划后出生人群(即2002—2013年出生),2014年高、中、低流行区HBsAg阳性率分别为0.88%(95<i>% CI</i>:0.66%~1.11%)、0.37%(95<i>% CI</i>:0.24%~0.49%)、0.71%(95<i>% CI</i>:0.48%~0.94%),抗-HBs阳性率分别为60.74%(95<i>%CI</i>:59.57%~61.90%)、59.46%(95<i>%CI</i>:58.44%~60.49%)、52.56%(95<i>%CI</i>:51.20%~53.92%),抗-HBc阳性率分别为3.30%(95<i>%CI</i>:2.87%~3.72%)、1.91%(95<i>%CI</i>:1.63%~2.20%)、2.25%(95<i>%CI</i>:1.85%~2.66%)。 <b>结论:</b> 中国乙型肝炎预防控制效果显著,2014年全国1~29岁人群HBsAg阳性率较1992年下降,在不同流行地区乙型肝炎疫苗纳入免疫规划后出生人群HBsAg阳性率均已降至1%以下。.

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  • (PMID = 28592086.001).
  • [ISSN] 0253-9624
  • [Journal-full-title] Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
  • [ISO-abbreviation] Zhonghua Yu Fang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Keywords] NOTNLM ; Hepatitis B / Hepatitis B vaccine / Serology
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