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1. Dudareva-Vizule S, Haar K, Sailer A, Jansen K, Hamouda O, Wisplinghoff H, Tiemann C, Pape E, Bremer V, Chlamydia trachomatis laboratory sentinel team: Establishment of a voluntary electronic Chlamydia trachomatis laboratory surveillance system in Germany, 2008 to 2014. Euro Surveill; 2017 Feb 09;22(6)
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishment of a voluntary electronic Chlamydia trachomatis laboratory surveillance system in Germany, 2008 to 2014.
  • In the period from 2008 to 2014, 3,877,588 CT tests were reported, 93% in women.
  • Women aged 20-24 years and men aged 25-29 years were the most frequently tested age groups.
  • The overall proportion of positive tests (PPT) among women was 3.9% and among men 11.0%.
  • The highest PPT among women was in the age groups 15-19 (6.8%) and 20-24 years (5.9%), and among men in the age groups 20-24 (19.2%), 15-19 (15.4%) and 25-29 years (14.8%).

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  • [Copyright] This article is copyright of The Authors, 2017.
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  • (PMID = 28205505.001).
  • [ISSN] 1560-7917
  • [Journal-full-title] Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
  • [ISO-abbreviation] Euro Surveill.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Keywords] NOTNLM ; Chlamydia trachomatis / Germany / laboratory surveillance / screening / sentinel / sexually transmitted infections / surveillance
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2. Sheppard C, Fry NK, Mushtaq S, Woodford N, Reynolds R, Janes R, Pike R, Hill R, Kimuli M, Staves P, Doumith M, Harrison T, Livermore DM: Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014. Euro Surveill; 2016 Dec 15;21(50)
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  • [Title] Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014.
  • We reviewed Streptococcus pneumoniae collected via: (i) the British Society for Antimicrobial Chemotherapy (BSAC) surveillances from 2001-2014;.
  • (ii) Public Health England's (PHE) invasive isolate surveillance from 2005-2014 and (iii) referral to PHE for resistance investigation from 2005-2014.
  • BSAC respiratory isolates were only serotyped in 2013/14 and 2014/15 (October to September); 15A was most prevalent serotype in both periods, comprising 9-11% of isolates, 38-48% of them with triple resistance.
  • Serotype 15A represented 0-4% of S. pneumoniae referred to PHE for reference investigation annually until 2008 but rose to 29% (2013) and 32% (2014).

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  • [Copyright] This article is copyright of The Authors, 2016.
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  • (PMID = 28006650.001).
  • [ISSN] 1560-7917
  • [Journal-full-title] Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
  • [ISO-abbreviation] Euro Surveill.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Keywords] NOTNLM ; Capsular serotypes / Pneumococcal conjugate vaccine / Streptococcus pneumoniae
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3. Webster SP, McBride A, Binnie M, Sooy K, Seckl JR, Andrew R, Pallin TD, Hunt HJ, Perrior TR, Ruffles VS, Ketelbey JW, Boyd A, Walker BR: Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™). Br J Pharmacol; 2017 Mar;174(5):396-408
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  • [Title] Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™).
  • BACKGROUND AND PURPOSE: Reducing glucocorticoid exposure in the brain via intracellular inhibition of the cortisol-regenerating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has emerged as a therapeutic strategy to treat cognitive impairment in early Alzheimer's disease (AD).
  • We sought to discover novel, brain-penetrant 11β-HSD1 inhibitors as potential medicines for the treatment of AD.
  • EXPERIMENTAL APPROACH: Medicinal chemistry optimization of a series of amido-thiophene analogues was performed to identify potent and selective 11β-HSD1 inhibitors with optimized oral pharmacokinetics able to access the brain.
  • Single and multiple ascending dose studies were conducted in healthy human subjects to determine the safety, pharmacokinetic and pharmacodynamic characteristics of the candidate compound.
  • RESULTS: UE2343 was identified as a potent, orally bioavailable, brain-penetrant 11β-HSD1 inhibitor and selected for clinical studies.
  • No major safety issues occurred in human subjects.
  • Plasma adrenocorticotropic hormone was elevated (a marker of systemic enzyme inhibition) at doses of 10 mg and above, but plasma cortisol levels were unchanged.
  • Following multiple doses of UE2343, plasma levels were approximately dose proportional and the terminal t<sub>1/2</sub> ranged from 10 to 14 h.
  • The urinary tetrahydrocortisols/tetrahydrocortisone ratio was reduced at doses of 10 mg and above, indicating maximal 11β-HSD1 inhibition in the liver.
  • Concentrations of UE2343 in the CSF were 33% of free plasma levels, and the peak concentration in CSF was ninefold greater than the UE2343 IC<sub>50</sub> .
  • CONCLUSIONS AND IMPLICATIONS: UE2343 is safe, well tolerated and reaches the brain at concentrations predicted to inhibit 11β-HSD1.
  • UE2343 is therefore a suitable candidate to test the hypothesis that 11β-HSD1 inhibition in brain improves memory in patients with AD.

  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
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  • [Copyright] © 2016 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
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  • (PMID = 28012176.001).
  • [ISSN] 1476-5381
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Grant] United Kingdom / British Heart Foundation / / RG/11/4/28734
  • [Publication-type] Journal Article
  • [Publication-country] England
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4. Chandrasekhar J, Dangas G, Yu J, Vemulapalli S, Suchindran S, Vora AN, Baber U, Mehran R, STS/ACC TVT Registry: Sex-Based Differences in Outcomes With Transcatheter Aortic Valve Therapy: TVT Registry From 2011 to 2014. J Am Coll Cardiol; 2016 Dec 27;68(25):2733-2744
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sex-Based Differences in Outcomes With Transcatheter Aortic Valve Therapy: TVT Registry From 2011 to 2014.
  • RESULTS: From 2011 to 2014, a total of 11,808 (49.9%) women and 11,844 (51.1%) men underwent TAVR.
  • Compared with male patients, female patients were older, with a lower prevalence of coronary artery disease, atrial fibrillation, and diabetes but a higher rate of porcelain aorta, lower glomerular filtration rate, and higher mean Society of Thoracic Surgeons score (9.0% vs. 8.0%; all p < 0.001).
  • In-hospital vascular complications were higher in women (8.27% vs. 4.39%; adjusted hazard ratio [HR]: 1.70; 95% CI: 1.34 to 2.14; p < 0.001) and a trend toward higher bleeding (8.01% vs 5.96%; adjusted HR: 1.19; 95% CI: 0.99 to 1.44; p = 0.06) was observed; however, 1-year mortality was lower (21.3% vs. 24.5%; adjusted HR: 0.73; 95% CI: 0.63 to 0.85; p < 0.001) in women than in men.

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  • [Copyright] Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
  • (PMID = 28007135.001).
  • [ISSN] 1558-3597
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; long-term outcomes / sex-based differences / transcatheter aortic valve replacement
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5. Li YY, Lu J, Wang XZ, Yang YY, Fei J, Zhang LP, Li Z, Li CS, Zuo Y: [Genotype distribution of human enteroviruses isolated from swage in Shanghai during year 2013-2014]. Zhonghua Yu Fang Yi Xue Za Zhi; 2017 Feb 06;51(2):154-159
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Genotype distribution of human enteroviruses isolated from swage in Shanghai during year 2013-2014].
  • : <b>Objective:</b> To explore the time and genotype distribution of human enterovirus (HEV) isolated from sewage in Shanghai in 2013-2014.
  • <b>Methods:</b> One sewage sample each was collected from two local sewage plants located in Minhang District and Jiading District on the same day at the day 24-28 of every month from 2013 to 2014.
  • <b>Results:</b> Among 185 NPEV strains, 178 strains were successfully sequenced and classified into 15 genotypes, including coxsackievirus group B (CVB) 2, 3, and 5; enteric cytopathic human orphan (ECHO) virus 1, 3, 6, 7, 11, 13, 19, 20, 24, 25, and 30; and coxsackievirus group A 4.
  • CVB5 and ECHO6 genotypes accounted for 33.5% (56 strains) and 24.9% (43 strains) of NPEV isolates, respectively.
  • ECHO6 strains were frequently isolated from June 2013 to July 2014.
  • Thereafter, the number of ECHO6 strains gradually reduced in the second half of 2014.
  • CVB5 strains demonstrated scattered distribution from 2013 to the first half of 2014 and gradually increased in the second half of 2014.
  • In 2013-2014, CVB5 strains comprised C6 and C8 subgenotypes, which belong to two transmission chains and show large differences compared with foreign strains isolated during the same period.
  • <b>Conclusion:</b> Poliovirus was identified as a vaccine strain in environmental surveillance from June 2013 to April 2014 in Shanghai.

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
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  • (PMID = 28219155.001).
  • [ISSN] 0253-9624
  • [Journal-full-title] Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
  • [ISO-abbreviation] Zhonghua Yu Fang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Keywords] NOTNLM ; Coxsackievirus infections / Echovirus infections / Enterovirus / Environmental monitoring
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6. Boffin N, Moreels S, Deblonde J, Van Casteren V: Four sexually transmitted infections (STIs) in Belgian general practice: first results (2013-2014) of a nationwide continuing surveillance study. BMJ Open; 2017 Jan 27;7(1):e012118
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  • [Title] Four sexually transmitted infections (STIs) in Belgian general practice: first results (2013-2014) of a nationwide continuing surveillance study.
  • OBJECTIVES: To describe and explore data from the surveillance of chlamydia, syphilis, gonorrhoea and genital warts by the Belgian Network of Sentinel General Practices (SGP) over the first 2 years (2013 and 2014) and to estimate the incidence of these 4 sexually transmitted infections (STIs).
  • The incidence of chlamydia in men was significantly higher in 2014 than in 2013.
  • Population characteristics were similarly distributed in 2013 and 2014.
  • Patient age or gender was missing from 35 episodes (11.4%).
  • Independent determinants of missingness of patient age or gender were the Flemish region (OR 3.46; 95% CI 1.02 to 11.73) and genital warts infection (OR 2.23; 95% CI 1.07 to 4.63).

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  • [Copyright] Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
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  • (PMID = 28131995.001).
  • [ISSN] 2044-6055
  • [Journal-full-title] BMJ open
  • [ISO-abbreviation] BMJ Open
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Belgium / PRIMARY CARE / PUBLIC HEALTH / sexually transmitted infections / surveillance data
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7. Cabrera-Gaytán DA, Niebla-Fuentes MD, Padilla-Velázquez R, Valle-Alvarado G, Arriaga-Nieto L, Rojas-Mendoza T, Rosado-Quiab U, Grajales-Muñiz C, Vallejos-Parás A: Association of Pulmonary Tuberculosis and HIV in the Mexican Institute of Social Security, 2006-2014. PLoS One; 2016;11(12):e0168559
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  • [Title] Association of Pulmonary Tuberculosis and HIV in the Mexican Institute of Social Security, 2006-2014.
  • The objective of this study was to analyze the incidence trends of pulmonary TB and HIV comorbidity and treatment outcomes according to HIV during the period 2006 to 2014 in the Mexican Institute of Social Security.
  • METHODS: Analyzed data from this registry including pulmonary tuberculosis patients aged 15 years and older who had been diagnosed during the years 2006 to 2014 in the Mexican Institute of Social Security.
  • RESULTS: During the study period, 31,352 patients were registered with pulmonary tuberculosis.
  • The incidence rate observed during 2014 was 11.6 case of PTB per 100,000.
  • The pulmonary TB with HIV incidence rate decreased by 16.3% during the study period (In women increase 4.81% and in man decrease 21.6%).

  • HIV InSite. treatment guidelines - Adherence to HIV Antiretroviral Therapy .
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  • (PMID = 28033402.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Hang LK, Do LP, Van TT, Nguyen SV, Hoang PV, Pham HT, Le TT, Tran HT, Vuong CD, Mai TQ: Viral co-infections among children with confirmed measles at hospitals in Hanoi, Vietnam, 2014. Asian Pac J Trop Med; 2017 Feb;10(2):171-174
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Viral co-infections among children with confirmed measles at hospitals in Hanoi, Vietnam, 2014.
  • OBJECTIVE: To characterize viral co-infections among representative hospitalized measles cases during the 2014 Hanoi outbreak.
  • RESULTS: Twenty-one cases (38.9%) showed evidence of infection with other respiratory viruses: 15 samples contained measles plus one additional virus, and 6 samples contained measles plus 2 additional viruses.
  • Adenovirus was detected as a predominant cause of co-infections (13 cases; 24.1%), followed by RSV (6 cases; 11.1%), A/H1N1pdm09 (3 cases; 5.6%), PIV3 (3 cases; 3.7%), Rhinovirus (3 cases; 3.7%) and hMPV (1 case; 1.96%).

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  • [Copyright] Copyright © 2017 Hainan Medical University. Production and hosting by Elsevier B.V. All rights reserved.
  • (PMID = 28237484.001).
  • [ISSN] 2352-4146
  • [Journal-full-title] Asian Pacific journal of tropical medicine
  • [ISO-abbreviation] Asian Pac J Trop Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Keywords] NOTNLM ; Co-infection / Measles virus / Respiratory viruses
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9. He YL, Yang HY, Yu CX, Zhang X, Yi QH, Ma ZL, Cha J, Xu XB, Zhang Q, Dai WJ, Qian WJ, Yin J, Zhu SJ, Xu Z: [Study of epidemic area on Tsutsugamushi disease in Taizhou from 2013 to 2014]. Zhonghua Yu Fang Yi Xue Za Zhi; 2017 Mar 06;51(3):252-256
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Study of epidemic area on Tsutsugamushi disease in Taizhou from 2013 to 2014].
  • <b>Methods:</b> From 2013 to 2014, Dongxing town hospital and Xingqiao town hospital were selected as specimen collection sites in Jingjiang city.
  • A total of 59 rodents were captured with cage night method in the survey sites at 5, 7, 9, 10, and 11 months in 2013, from which, the spleen, liver, and kidney specimens were selected.
  • 27 Chigge mites were collected by small blackboard method and the density of mites was 0.12 for each blackboard, among which 3 larvae and 24 nymphs were found.
  • 33 Chigger mites were collected from the ears of 3 Smelly shrew, and the density of the mite was 11 per mouse.
  • <b>Conclusion:</b> There was a high density of mice in the epidemic area from May to November and the species of the chigger mites were Chigger mites in Taizhou.
  • According to the above-mentioned results, it was considered that the scrub typhus epidemic area of Taizhou city has the natural foci of scrub typhus.

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  • (PMID = 28260341.001).
  • [ISSN] 0253-9624
  • [Journal-full-title] Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
  • [ISO-abbreviation] Zhonghua Yu Fang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Keywords] NOTNLM ; Epidemic foci / Polymerase chain reaction / Scrub Typhus
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10. Li J, Tang HL, Han J, Xu J, Shen ZY, Lai WW, Shi YH, Sun DY, Ni MJ, Mao YR: [HIV transmission in newly reported HIV infected couples before diagnoses in five provinces, China, 2011-2014]. Zhonghua Liu Xing Bing Xue Za Zhi; 2016 Nov 10;37(11):1497-1502
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [HIV transmission in newly reported HIV infected couples before diagnoses in five provinces, China, 2011-2014].
  • <b>Methods:</b> The information about newly reported HIV infected couples in Yunnan, Guangxi, Sichuan, Henan and Xinjiang provinces (autonomous region) were collected from National HIV/AIDS Information System from 2011 to 2014.
  • <b>Results:</b> A total of 48 931 HIV cases in couples were included in this study, among whom 12 051(24.6%) were sero-concordant couples, indicating HIV transmissions occurred between them.
  • Multivariate logistic regression analysis showed that those who were females (<i>OR</i>=1.98, 95%<i>CI</i>: 1.89-2.08), aged >45 years (45-59 yrs: <i>OR</i>=1.32, 95% <i>CI</i>: 1.23-1.42; >60 yrs: <i>OR</i>=1.72, 95% <i>CI</i>: 1.58-1.86), had educational level of middle school education or below (illiteracy and primary school: <i>OR</i>=1.33, 95%<i>CI</i>: 1.23-1.44; middle school: <i>OR</i>=1.19, 95% <i>CI</i>: 1.10-1.28), were farmers or migrate workers (<i>OR</i>=1.23, 95% <i>CI</i>: 1.17-1.30), were infected through injecting drug use or heterosexual intercourse (injecting drug use: <i>OR</i>=1.33, 95% <i>CI</i>: 1.03-1.72; heterosexual intercourse: <i>OR</i>=3.65, 95% <i>CI</i>: 2.89-4.61), had CD<sub>4</sub><sup>+</sup>T cells of <500 cells/μl (<200 cells/μl: <i>OR</i>=5.05, 95%<i>CI</i>: 4.62-5.52; 200-349 cells/μl: <i>OR</i>=3.58, 95%<i>CI</i>: 3.26-3.93; 350-500 cells/μl: <i>OR</i>=2.14, 95%<i>CI</i>: 1.94-2.36), reported unprotected sexual behaviors (<i>OR</i>=1.56, 95% <i>CI</i>: 1.49-1.64), were more likely to infect their couples before diagnosis.
  • The HIV transmission proportion between couples before diagnosis decreased significantly from 28.9% (2 631/9 102) in 2011 to 25.5% (3 009/11 787) in 2014 among those infected through heterosexual intercourse.

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  • (PMID = 28057142.001).
  • [ISSN] 0254-6450
  • [Journal-full-title] Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
  • [ISO-abbreviation] Zhonghua Liu Xing Bing Xue Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article; English Abstract
  • [Publication-country] China
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